Evolution, And Phylogeny Of Herv-S Family In Some Closely Related Primates

Volume 17 , Issue 4 , December 2015 , Pages 153-164

Authors

¹ College of Science, University of Sulaimani.

Human endogenous retroviral element S-family (HERV-S) has been present within

the human genome as well as various closely related primates. The expression

pattern, copy number, chromosomal locations of the proviral element have been

extensively studied. Here, we analyse the pol fragment of the HERV-S in human

tissues, cancer cell lines and in seven other related primates. Phylogenetic analysis of

the HERV-S pol gene suggests division of the family into two groups among the

tested species that have arisen throughout the primate evolution by gene duplication

as well as other genetic alterations. Also, the tree analysis of human tissues and

cancer cells suggest that expression of the chromosome X pol fragment is identical to

expression of the pol fragment in cancerous cells more than its relation to the pol

sequence on other human chromosomes. To sum up, our data provide a clarification

about the dynamic evolutionary characteristics as well as phylogenetic relationships

of HERV-S family pol gene in primates.

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