Acute toxicity of Pistacia atlantica green seeds on Sprague- Dawley rat model

Volume 19 , Issue 3 , December 2017 , Pages 9-16

Authors

Hiewa Othman Dyary 1 ; Heshu Sulaiman Rahman 2 ; Hemn Hassan Othman 2 ; Snur Mohammad 1 ; Rasedee Abdullah 3

1 College of Veterinary Medicine, University of Sulaimani, Kurdistan Region, Iraq

2 Department of Medical Laboratory Science, College of Health Science, Komar University of Science and Technology-Sulaimani, Kurdistan Region, Iraq

3 Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

DOI logo 10.17656/jzs.10628

Keywords

Abstract

The acute toxic effect of the aqueous extract of Pistacia atlantica green seeds was investigated in groups of Sprague-Dawley rats at oral doses of 200, 400, and 800 mg/kg body weight. After 14 days, there was no significant difference (p>0.05) in behavior, food and water consumption, body weight gain, and hematological and serum biochemical parameters between untreated control and extract-treated rats. There were lesions in the liver and kidney indicating that aqueous P. atlantica seed extract causes some hepatoxicity and nephrotoxicity in rats.

Statistics
  • Article view460
  • Downloads0
  • Published at20 December 2017

  • RIS
  • BibTeX
  • EndNote
  • Mendeley
  • APA (7th edition)
  • MLA (9th edition)
  • Chicago
  • Harvard
  • IEEE
  • Vancouver