Hemodynamic ,thyroid and immunomodulater effects of cannabinoid in rats.

Volume 18 , Issue 2 , February 2016 , Pages 71-80

Authors

¹ Department of Biology, College of Science, Salahaddin University - Erbil, Kurdistan Region, Iraq,

The aims of the present study are to investigate the cannabinoid effects on serum

monocyte chemoattractant protein-1 (MCP-1), Troponin-1 ,liver and renal test

parameters. The experimental rats were divided into three groups, the first group served

as a control, and the animals were injected with normal saline. In the second group,

animals were injected with cannabis (5 mg/kg, intraperitonial), while in the third group

animals were injected with cannabis (10 mg/kg). After the course of the experiment,

systolic blood pressure (SBP) tended to reduce significantly in the second dose of

cannabis administered rats. Serum nitric oxide (NO) level slightly increased in dose

dependent manner but it did not reach the level of significance. Serum level of

malondialdehyde (MDA), troponin-T, MCP-1 and serum total bilirubin were

significantly increased in the second dose of cannabis administration as compared to

control rats. Neither triiodothyronin (T3) nor tetraiodothyronin (T4) hormones had

statistically changed in cannabis group comparing with the control rats. Furthermore,

serum uric acid reduced in cannabis group as compared with control. In conclusions, for

the first time, our findings suggested that cannabis could affect immune system through

MCP-1 elevation. As well as, cannabis may affect cardiac and liver functions via

increasing troponin-T and bilirubin levels.

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