Synthesis and Characterization of some new 2,5-disubstituted- 1,3,4-oxadiazole derivatives Containing Antipyrine moiety.

Volume 18 , Issue 2 , February 2016 , Pages 11-26

Authors

¹ Faculty of Science and Science Education, School of Science, Department of Chemistry, University of Sulaimani, Kurdistan region, Iraq

Some new 2,5-disubstituted-1,3,4-oxadiazolels of type (E)-4-((1-(5-(substitutedphenyl)

1,3,4-oxadiazol-2-yl)pro-1-en-2-yl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-

one were synthesized in (60-81%) yield under solvent free conditions using grinding

technique through the reaction of hydrazide intermediate with benzaldehyde or different

substituted benzaldehydes in the presence of catalytic amounts of iodine molecular as a

single step. The structures of all the synthesized compounds were confirmed on the basis

of their physical properties, IR, 1H-NMR and Mass spectral data.

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