Cytological and Histological Effect of Paracetamol on the Testis and Liver in Albino Mice Mus musculus

Volume 16 , Issue 4 , October 2014 , Pages 59-67

Authors

¹ Department of Biology-College of Education, University of Salahaddin

The purpose of this study is to evaluate the acute toxicity effects of pure paracetamol tablets

on laboratory mice. In this study Mus musculus mice (6-8) weeks old were used. The toxicity effects

were evaluated on fifteen mice, in which they were divided equally into three groups, each one

consists of five individual mice. The first group was labeled as a vehicle group and received 5mL/kg

DW. The second and third groups were labeled as experimental groups which received 2 g/kg and 5

g/kg of paracetamol respectively. After fifteen days the animals were examined for toxicity signs and

then the liver and testis were processed for histological examinations. Furthermore, the sperm

abnormalities were recorded. The results of this study demonstrated that the low dose did not show

any morphological changes while some changes such as shivering, nausea and mortality were

manifested after administration of high dose of paracetamol. Many histological changes have been

observed after high dose treatment of paracetamol, the frequencies of abnormal sperm were

increased as well. Therefore, Paracetamol, which is believed to be a strong pain killer for the

hangover headache may damage liver and testis when consumes beyond the recommended dose.

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